Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (607)   No Age Effect (103)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP (147)   Locus (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs969845 — 5.87 7.22e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs327519 PAX4 (for males) 5.70 0.004 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs327512 — 5.55 0.005 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs2072454, rs2293347, rs3807362, rs884225 EGFR (for females) 4.11 0.003 137 vs 213 — Korean Mean age 90 — CGCA Genome-Wide Association Study 19641380
    rs1450740, rs1450741, rs1562818, rs1980042, rs1027989, rs 1546518, rs3968371 — 3.72 0.002 137 vs 213 — Korean Mean age 90 — CTCCGCA Genome-Wide Association Study 19641380
    rs11005328 ZWINT 3.16 0.002342056 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs7583529 CFLAR 3.15 6.45e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7873259 ANKRD19 3.14 1.18e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1584547 — 2.96 8.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs17154903 Intergenic 2.68 7.31e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs731287 — 2.51 9.88e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2070325 LPLUNC4 2.42 5.98e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10923806 — 2.30 7.24e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1383582 Intergenic 2.21 2.46e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — A — Genome-Wide Association Study 21782286
    rs268300 Intergenic 2.13 4.05e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs671 ALDH2 (for males) 2.11 0.009 137 vs 213 — Korean Mean age 90 — A Genome-Wide Association Study 19641380
    rs1980042 LYN (for males) 2.10 0.006 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
    rs1979128 — 2.10 0.006 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs1893132 Intergenic 2.07 3.19e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs964403 SUMF1 2.07 4.91e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs3864051 SUMF1 2.07 5.49e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs4505466 SH3BP4 2.06 8.31e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2290889 SYK 2.00 9.14e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs7864625 SYK 2.00 1.01e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — G Genome-Wide Association Study 21418511
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    • 25 of 710 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue