Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    IL10 haplotypes IL10 — 0.05 237 vs 90 — Turkish Age range: 65-99 — −1082G, −819C, −592C Candidate Region/Gene 21299522
    IL10 haplotypes IL10 — 0.05 60 vs 60 — Bulgarian Age range: 65-99 — −1082G, −819C, -592C Candidate Region/Gene 21299522
    TNF haplotypes TNF — 0.01 60 vs 50 — Bulgarian Age range: 65-99 — −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G Candidate Region/Gene 21299522
    AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 — Italian Centenarians M, S Z Candidate Region/Gene 17048073
    HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    XbaI APOB 1.30 0.03 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 — X+X+ Candidate Region/Gene 17393087
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 — Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
    rs1800871 IL-10 — 0.0026 500 — Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    G477T SIRT3 — 0.0272 801 — Italian 120 subject aged 100 or older GT TT Candidate Region/Gene 14580859
    rs1061170 CFH 1.78 0.005 491 with follow-up during 4 years — Finn >90 — TT Candidate Region/Gene 19000922
    rs9330200 TUBB4B — 6e-53 5036 — American 28-70 AA, AT TT Genome-Wide Association Study 22174011
    rs9536314 KL — 0.007 216 vs 309 — Ashkenazi Jewish >95 — TG (genotype) Candidate Region/Gene 15677572
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian — G,C T Candidate Region/Gene 19249341
    rs2755209 FOXO1 0.80 0.0046 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
    rs2755213 FOXO1 0.75 7.4e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
    rs2802292 FOXO3 1.36 2.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 G T Candidate Region/Gene 19793722
    rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs139170 PARVG — 0.00332 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs4648884 RUNX3 — 0.00992 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs10937739 PPP2R2C — 0.00404 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs13053175 RAC2 — 0.00697 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs4148544 ABCC4 — 0.00977 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs2370413 CACNA1C — 0.0011 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs2826891 NCAM2 — 0.00402 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    • Page 1 of 42
    • 25 of 1027 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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