Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs12206094 FOXO3 1.38 0.0076 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    rs699947 VEGFA 1.43 0.008 166 vs 324 — Italian 85-99 (mean 89.8±2.8) C A Candidate Region/Gene 17574707
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.46 0.01 488 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR13 alleles DR13 Candidate Region/Gene 9425225
    TNF haplotypes TNF — 0.01 60 vs 50 — Bulgarian Age range: 65-99 — −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G Candidate Region/Gene 21299522
    rs2802290 FOXO3 1.26 0.01 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs9486902 FOXO3 1.40 0.0118 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs648802 PERP 1.29 0.012 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603
    −1190G/A VEGFA 1.39 0.014 166 vs 324 — Italian 85-99 (mean 89.8±2.8) G A Candidate Region/Gene 17574707
    rs1008438 HSPA1A 3.86 0.016 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    rs4946935 FOXO3A 1.48 0.018 302 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 117 A — Candidate Region/Gene 19489743
    rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
    rs1935949 FOXO3A 1.46 0.019 299 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114 T — Candidate Region/Gene 19489743
    rs2153960 FOXO3A 1.16 0.019 300 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 — — Candidate Region/Gene 19489743
    rs1801270 CDKN1A 0.44 0.02 184 vs 184 — Italian 100 A C Candidate Region/Gene 20126416
    HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 — Chinese >93 Cw3, Cw6. Cw7 — Candidate Region/Gene 9147371

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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