Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1801133 MTHFR 6.00 0.014 224 vs 441 — Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    AGT AGT — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    rs1801133 MTHFR — 0.029 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — C Candidate Region/Gene 15621215
    - F5 — 0.045 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 A — Candidate Region/Gene 15621215
    rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs28969505 YTHDF2 — 0.047 136 vs 275 — Italian Mean age 101 — 15-15 (205 bp) Candidate Region/Gene 16799135
    rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    Not specified REN — 0.029 157 vs 218 — Italian Centenarians 11 — Candidate Region/Gene 15105583
    M/T235 AGT 0.67 0.53 187 vs 201 — Danish centenarians T — Candidate Region/Gene 11602206
    −1082 G/A IL10 — 0.025 190 vs 260 — Italian >99 years old — G Candidate Region/Gene 11857058
    rs1800896 IL10 3.10 0.0003 142 vs 153 — Mean age 67 AA GG Candidate Region/Gene 15466015
    --1082G-->A IL10 — 0.0001 109 (oldest old men) vs 263 (healthy controls) — Italian >95 A — Candidate Region/Gene 15466015
    rs1800896 IL-10 3.00 0.0003 142 vs 153 — Italian Mean age 67 AA GG Candidate Region/Gene 15466015
    IL10 haplotypes IL10 — 0.05 60 vs 60 — Bulgarian Age range: 65-99 — −1082G, −819C, -592C Candidate Region/Gene 21299522
    IL10 haplotypes IL10 — 0.05 237 vs 90 — Turkish Age range: 65-99 — −1082G, −819C, −592C Candidate Region/Gene 21299522
    G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian — G,C T Candidate Region/Gene 19249341
    rs11585393 FOXO6 1.04 0.531 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs7539614 FOXO6 1.02 0.739 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs7547654 FOXO6 1.08 0.2 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs11581271 FOXO6 0.91 0.131 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs1317558 FOXO6 1.11 0.257 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
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    • 25 of 58 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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