Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3865444 CD33 — 0.442 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs3764650 ABCA7 — 0.135 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs1674159 NDUFA11 1.41 0.000520159 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs11086106 PGPEP1 1.77 0.000263101 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs7246865 MYO9B 1.25 0.000164604 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4802234 CEACAM16 1.36 9.22e-06 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs10412199 ATCAY 0.91 3.02e-06 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — — A Genome-Wide Association Study 21782286
    rs2708754 ZNF331 0.94 5.79e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — — A Genome-Wide Association Study 21782286
    rs2302951 GRWD1 1.51 7.59e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs3212948 ERCC1 — 0.1062 288 vs 554 — Calabrian 90+, median 92 — — Candidate Region/Gene 22576335
    VNTR DC-SIGNR — 0.041 361 vs 342 — Chinese >90 non-6/7 genotype 6/7 genotype Candidate Region/Gene 20003397
    HP1/2 common polymorphism HP — 0.05 200 (cases) vs 539 (initial) (initial) — Italian >88 — — Candidate Region/Gene 21703254
    Asp312Asn ERCC2 — 0.05 149 vs 413 — Polish Mean age 101.1 — — Candidate Region/Gene 19707883
    Arg156Arg ERCC2 — 0.05 149 vs 413 — Polish Mean age 101.1 — — Candidate Region/Gene 19707883
    Lys751Gln ERCC2 — 0.017 149 vs 413 — Polish Mean age 101.1 homozygous (Lys/Lys, Gln/Gln) heterozygous (Lys/Gln) Candidate Region/Gene 19707883
    rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs3220637 XRCC1 — 0.0005 430 (case) vs 290 — British Mean age 70 16 — Candidate Region/Gene 16518718
    rs25487 XRCC1 — 0.51 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs1799782 XRCC1 — 0.658 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
    rs72533289 KIR2DS4 — 1.0 180 vs 180 — Irish Mean age 89 — — Candidate Region/Gene 15130674
    Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
    rs1800471 TGFB1 — 0.034 172 vs 247 — Italian 90-103 GC (genotype) — Candidate Region/Gene 15569360
    TGFB1 haplotypes TGFB1 — 0.05 60 vs 40 — Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G; −988 C/C, −800 G/G — Candidate Region/Gene 21299522
    TGFB1 haplotypes TGFB1 — 0.05 297 vs 130 — Turkish, Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G — Candidate Region/Gene 21299522
    • Page 1 of 3
    • 25 of 67 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue