Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    KIR2DS3 haplotypes KIR2DS3 0.05 100 vs 100 Irish Age range: 65-99 Candidate Region/Gene 21299522
    Arg156Arg ERCC2 0.05 149 vs 413 Polish Mean age 101.1 Candidate Region/Gene 19707883
    Asp312Asn ERCC2 0.05 149 vs 413 Polish Mean age 101.1 Candidate Region/Gene 19707883
    - APOC1 0.05 282 vs 200 British 84 and over Candidate Region/Gene 9105559
    rs3212948 ERCC1 0.1062 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs2302951 GRWD1 1.51 7.59e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs2708754 ZNF331 0.94 5.79e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs10412199 ATCAY 0.91 3.02e-06 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs1799782 XRCC1 0.658 430 vs 290 British Mean age 70 Candidate Region/Gene 16518718
    rs25487 XRCC1 0.51 430 vs 290 British Mean age 70 Candidate Region/Gene 16518718
    rs72533289 KIR2DS4 1.0 180 vs 180 Irish Mean age 89 Candidate Region/Gene 15130674
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
    E4 APOE 0.013 35 vs 125 Chinese 90 years or over Candidate Region/Gene 11780357
    rs3745544 INSR 0.441 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs3745546 INSR 0.168 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs3745548 INSR 0.057 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs2252673 INSR 0.083 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs1799817 INSR 0.205 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs2288404 INSR 0.277 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs4420638 APOE 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) Caucasian, European 90 Genome-Wide Association Study 23286790
    rs429358, rs7412 APOE 0.0212 60 vs 89 African European Range: 20-59 Candidate Region/Gene 20569235
    rs3220637 XRCC1 0.0005 430 (case) vs 290 British Mean age 70 16 Candidate Region/Gene 16518718
    rs4802234 CEACAM16 1.36 9.22e-06 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs7246865 MYO9B 1.25 0.000164604 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
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    • 25 of 67 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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