Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4938180 IGSF4 1.91 2.16e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs189037 ATM 1.85 0.037 67 vs 61 — Italian Centenarians — — Candidate Region/Gene 22960875
    rs189037 ATM 1.85 0.028 128 vs 150 — Italian — — — - 22960875
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old C A Candidate Region/Gene 22406557
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 C — Candidate Region/Gene 22406557
    rs10502005 MMP20 1.48 2.42e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs189037 ATM 1.45 0.12 128 vs 150 — Italian Mean age 98.7 +/- 5.1 — — Candidate Region/Gene 22960875
    rs1470196 KIAA1377 1.33 0.000498694 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4755936 SYT13 1.19 0.003578524 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs651922 DCPS 1.19 4.75e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4237774 OR56A1 1.18 0.000637699 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs894558 NAV2 1.13 0.004524209 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs7127390 IGSF4 1.13 0.001091248 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    HRAS1 3'VNTR HRAS 1.13 0.551 234 vs 467 — Italian Minimum age 100 a3 non-a3 Candidate Region/Gene 11943467
    3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 — Italian centenarians a3 allele (see notes) — Candidate Region/Gene 11943467
    rs4936894 VWA5A 1.11 3.38e-07 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — A — Genome-Wide Association Study 21782286
    rs216493 PLEKHA7 1.10 0.001543457 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1815739 ACTN3 1.03 0.1 59 vs 283 — Caucasian, Spaniard centenarians (aged 100–108 years) — — Candidate Region/Gene 21407828
    HUMTHO1.STR TH 0.85 0.005 210 vs 755 — Italian 100+ — 10* (imperfect allele 10) Candidate Region/Gene 12297342
    rs2509049 H2AFX 0.63 0.017 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    rs2073586 ABCC8 0.48 8.15e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
    rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
    rs2060793 CYP2R1 — 0.04 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) A — Candidate Region/Gene 23128285
    rs3829251 NADSYN1 — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
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    • 25 of 81 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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