Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs11235972 UCP3 0.029 908 vs 708 Danish 93 A Candidate Region/Gene 22743239
    rs1685354 UCP3 0.762 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    rs3781907 UCP3 0.05 908 vs 708 Danish 93 G Candidate Region/Gene 22743239
    rs647126 UCP3 0.447 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    G477T SIRT3 0.0272 801 Italian 120 subject aged 100 or older GT TT Candidate Region/Gene 14580859
    APOA1-MspI-RFLP A/P alleles APOA1 0.045 413 vs. 571 Italian median age 101 A P Candidate Region/Gene 12556235
    rs189037 ATM 0.004 875 vs 886 Chinese mean 94.6 CT Candidate Region/Gene 20816691
    VNTR in intron 5 (DeltaEF1 site) SIRT3 8e-05 242 vs 703 Italian Median age 102 2b Candidate Region/Gene 15676284
    VNTR in intron 5 (GATA3 site) SIRT3 0.025 242 vs 703 Italian Median age 102 2a Candidate Region/Gene 15676284
    many SNPs TH 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
    many SNPs IGF2 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
    many SNPs INS 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
    many SNPs HRAS1 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
    rs939915 SIRT3 0.0145 2461 samples (cases and controls combined) Italian Candidate Region/Gene 19367319
    rs11235972 UCP3 0.029 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) Danish 93 A Candidate Region/Gene 22743239
    rs3781907 UCP3 0.05 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) Danish 93 G Candidate Region/Gene 22743239
    - SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs800140 TSPAN32 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs189037 ATM 1.85 0.028 128 vs 150 Italian - 22960875
    apoAIV(360:His) APOA4 0.005 119 (see notes) vs 264 French 74.29 ∓ 8.46 ApoAIV-1_x000D_, by the order of the sentence - I'm assuming it's Glutamine = G Candidate Region/Gene 9533408
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    • 25 of 81 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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