Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    Igf2 insulin-like growth factor 2 Altered imprinting of Igf2 does not affect longevity [20550518]. House mouse
    APD1 Actin Patches Distal 1 Although APD1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of APD1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. Budding yeast
    rrf-1 RNA-dependent RNA polymerase Family Although rrf-1(pk1417) mutants seem to have elevated DAF-16 activity (as sod-3 transcript level is increased) the mean and maximum lifespan or ability to withstand elevated temperature is not different from wild-type [22574120]. Nematode
    SSN2 Suppressor of SNf1 Although SSN2 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of SSN2 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. Budding yeast
    ANKRD19 ankyrin repeat domain 19, pseudogene ANKRD19 was not found to be associated with longevity [21612516]. Human
    APOE + TOMM40 APOE + TOMM40 was not found to be associated with longevity [21418511]. APOE + TOMM40 was not found to be associated with longevity [23040522]. Human
    ATF4 ATF4 was not found to be associated with longevity [23770741]. Human
    ATXN1 ataxin 1 ATXN1 was not found to be associated with longevity [21612516]. Human
    B9D2 B9 protein domain 2 B9D2 was not found to be associated with longevity [15569360]. Human
    BIN1 bridging integrator 1 BIN1 was not found to be associated with longevity [22445811]. Human
    HFE hemochromatosis C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263]. Human
    CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase CAD was not found to be associated with longevity [15621215]. Human
    CBL CBL was not found to be associated with longevity [23770741]. Human
    CCL5 chemokine (C-C motif) ligand 5 CCL5 was not found to be associated with longevity [22265023]. Human
    CCR5 chemokine (C-C motif) receptor 5 CCR5 was not found to be associated with longevity [22265023]. Human
    CCR5 chemokine (C-C motif) receptor 5 CCR5 was not found to be associated with longevity [22265023]. Human
    CD2AP CD2-associated protein CD2AP was not found to be associated with longevity [22445811]. Human
    CD33 CD33 molecule CD33 was not found to be associated with longevity [22445811]. Human
    CDH23 cadherin-related 23 CDH23 was not found to be associated with longevity [21612516]. Human
    CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A was found to be associated with longevity [20126416]. CDKN1A was found to be associated with longevity [20126416]. CDKN1A was not found to be associated with longevity [20126416]. Human
    CDKN2B-AS1 CDKN2B antisense RNA 1 CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. Human
    CFLAR CASP8 and FADD-like apoptosis regulator CFLAR was not found to be associated with longevity [21612516]. Human
    CLU clusterin CLU was found to be associated with longevity [16804001]. CLU was not found to be associated with longevity [22445811]. Human
    COQ7 coenzyme Q7 homolog, ubiquinone (yeast) COQ7 was not found to be associated with longevity [18765803]. Human
    CR1 complement component (3b/4b) receptor 1 (Knops blood group) CR1 was not found to be associated with longevity [22445811]. Human
    Factors are an extension of GenAge and GenDR.

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