Authors: Schupf N; Barral S; Perls T; Newman A; Christensen K; Thyagarajan B; Province M; Rossi WK; Mayeux R
Abstract: Exceptional longevity is associated with substantial heritability. The epsilon4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the epsilon2 allele with decreased mortality, although inconsistently. Offspring from long-lived families and spouse controls were recruited at 3 sites in the United States and Denmark. We used generalized estimating equations to compare the likelihood of carrying risk alleles in offspring (n = 2307) and spouse controls (n = 764), adjusting for age, sex, level of education, and family membership. The likelihood of carrying an APOE epsilon4 allele or a G allele in rs2075650 was lower (odds ratio [OR], 0.75; p = 0.005 and OR, 0.70; p = 0.002) and the likelihood of carrying an APOE epsilon2 allele was higher (OR, 1.5; p = 0.007) among family members in the offspring generation than among their spouse controls. Our findings support the hypothesis that both reduction in the frequency of the epsilon4 allele and increase in the frequency of the epsilon2 allele contribute to longevity.
|
Journal: Neurobiology of aging Volume: 34 Issue: 4 Pages: 1287-91 Date: Oct. 9, 2012 PMID: 23040522 |
Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi WK, Mayeux R (2013) Apolipoprotein E and familial longevity. Neurobiology of aging 34: 1287-91.
Comment on This Data Unit