The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.

Authors: Pinós T; Fuku N; Cámara Y; Arai Y; Abe Y; Rodríguez-Romo G; Garatachea N; Santos-Lozano A; Miro-Casas E; Ruiz-Meana M; Otaegui I; Murakami H; Miyachi M; Garcia-Dorado D; Hinohara K; Andreu AL; Kimura A; Hirose N; Lucia A

Abstract: The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n = 152, 128 women, 100-111 years; healthy controls: n = 343, 212 women, age <50 years; CAD controls: n = 98, 32 women, age </=65 years) and Japanese (centenarians: n = 742, 623 women, 100-115 years; healthy controls: n = 920, 511 women, < 60 years; CAD controls: n = 395, 45 women, age </=65 years). The frequency of the "risk" C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P = 0.088) or CAD controls (55.1 %, P = 0.078), and significant differences were found in genotype distributions (P = 0.034 and P = 0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P = 0.602), but it was significantly lower in the former than in CAD controls (57.2 %, P < 0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.

Journal: Age (Dordrecht, Netherlands)
Volume: 36
Issue: 2
Pages: 933-43
Date: Oct. 29, 2013
PMID: 24163049
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Citation:

Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A (2014) The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordrecht, Netherlands) 36: 933-43.


Longevity Variant Associations (p-value):
  • rs1333049 (0.088)
  • rs1333049 (0.602)
  • rs4998557 (0.52)
  • rs2070424 (0.77)
  • rs1041740 (0.998)
  • rs6917589 (0.741)
  • rs2842980 (0.689)
  • rs7855 (0.842)
  • rs8031 (0.186)
  • rs5746141 (0.601)
  • rs5746136 (0.354)
  • rs5746133 (0.466)
  • rs4880 (0.552)
  • rs13306703 (0.764)
  • rs8192287 (0.955)
  • rs699473 (0.613)
  • rs17881426 (0.425)
  • rs1007991 (0.679)
  • rs2536512 (0.942)
  • rs8192291 (0.144)
  • rs8192290 (0.428)

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