| VPS36 | Vacuolar Protein Sortin 36 | VPS36 deletion mutants have a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. | Budding yeast |
| Vitamin D receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | Vitamin D receptor was not found to be associated with longevity [21051524]. | Human |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| unc-46 | UNCoordinated 46 | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Nematode |
| SOD1 | superoxide dismutase 1, soluble | Ubiquitous overexpression of SOD1 does not extend lifespan in mice. Homozyous transgenic mice with two- to five-fold overexpression of SOD1 in various tissues exhibit a light reduction in lifespan. Hemizygous transgenic mice, with 1.5- to 3-fold overexpression of SOD1 display no difference in lifespan compared with nontransgenic litermate controls [10719757]. Transgenic mice with a mutant SOD1 transgene develop neuronal cytoskeletal lesions resembling the human amytrophic lateral sclerosis (ALS) phenotype [8610185]. Transgenic mice overexpressing SOD1 (and having 3.1-fold higher cellular Cu,Zn SOD activity in the brain) have reduced infarct size following experimental cerebral ischemia [1763030].SOD1 was not found to be associated with longevity [24163049]. | Human |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
| TSPAN32 | tetraspanin 32 | TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. | Human |
| NAC | N-acetyl cysteine | Treatment with 10 mM of NAC has no effect on the lifespan of wild-type, but fully abolishes the increased longevity of nuo-6 and severly limits that of isp-1. At high concentration (> 10-15 nM) NAC can be become deleteroius even on the wild-type [21151885]. | Nematode |
| Vitamin C | — | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Nematode |
| — | (-)-epidcatechin | Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. | Nematode |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | Transgenic lines overexpressing either human wild-type or mutant (A53T) forms of the SNCA (alpha-synclein) gene under a pan-neuronal promoter live on average about 25% longer, even in weak (m577) and strong (e1370) daf-2 mutant backgrounds, and exhibited decreased pharyngeal pumping and egg-laying. Wild-type SNCA crossed into eat-2(ad1113) does not significantly effect lifespan compared to that of the background strain. Pumping rate in wild-type SCNA and A53T SCNA overexpression mutants were less than control already at day 1 of adulthood. The attenuation of lifespan exptesion by SNCA overexpression by growing on thick bacterial lawns, suggests that DR may explain some fo the effects on lifespan. SCNA overexpression increases average lifespan by 21.3% (wild-type) and 16.3% (A53T) [16782295].
Mutation of SCNA (alias alpha synclein) is associated with Parkinson's disease [9197268], which is characterized with resting tremor, rigidity bradykinesia and posural instability that are associated with selective neurodegeneration of the pigmented neurons in the brain stem (substantia nigra and locus coerues) and the presence of intracytoplasmic inclusion bodies (Lewy bodies) [Yamamura et al. 1973]. The mutated protein (Ala53Thr or Ala30Pro) may misfold, aggregate and resist degradation [11433374].SNCA was found to be associated with longevity [22912757]. SNCA was not found to be associated with longevity [22912757]. | Human |
| TPO | thyroid peroxidase | TPO was not found to be associated with longevity [9050915]. | Human |
| TPI1 | triosephosphate isomerase 1 | TPI1 was not found to be associated with longevity [18510744]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 | TNFSF11 was not found to be associated with longevity [19641380]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| TMEM61 | transmembrane protein 61 | TMEM61 was not found to be associated with longevity [21612516]. | Human |
| unc-80 | UNCoordinated | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Nematode |
| unc-79 | UNCoordinated | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Nematode |
| unc-49 | UNCoordinated 49 | The unc-49(e382) allele has no significant effect on lifespan [9789046].
unc-49 mutants are uncoordinated [4366476]. | Nematode |
| unc-47 | UNCoordinated 47 | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Nematode |
| SOD2 | superoxide dismutase 2, mitochondrial | The SOD2 rs2758331 has been correlated with exceptional longevity in a plethora of genetic signatures [22279548].SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [17903295]. SOD2 was found to be associated with longevity [15621215]. SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [19428448]. SOD2 was not found to be associated with longevity [9887369]. SOD2 was found to be associated with longevity [22279548]. SOD2 was not found to be associated with longevity [24163049]. | Human |
