| TXNRD1 | thioredoxin reductase 1 | TXNRD1 was found to be associated with longevity [22406557]. | Human |
| Txnrd1 | Thioredoxin reductase 1, cytoplasmic | Txnrd1 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Two alleles, 44-bp insertion (l allele) or deletion (s allele) in the promoter region of SLC6A4, were examined in 265 Japanese centenarians and control subjects. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women [16095668].SLC6A4 was found to be associated with longevity [22985157]. | Human |
| TUSC3 | tumor suppressor candidate 3 | TUSC3 was found to be associated with longevity [22279548]. | Human |
| TUBB4B | tubulin, beta 2C | TUBB4B was found to be associated with longevity [22174011]. | Human |
| TTC6 | tetratricopeptide repeat domain 6 | TTC6 was found to be associated with longevity [22279548]. | Human |
| TSPAN32 | tetraspanin 32 | TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. | Human |
| TSH-B | thyroid stimulating hormone, beta | TSH-B was found to be associated with longevity [19837933]. TSH-B was found to be associated with longevity [19837933]. | Human |
| TRIM25 | tripartite motif containing 25 | TRIM25 was found to be associated with longevity [22279548]. | Human |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | Transgenic lines overexpressing either human wild-type or mutant (A53T) forms of the SNCA (alpha-synclein) gene under a pan-neuronal promoter live on average about 25% longer, even in weak (m577) and strong (e1370) daf-2 mutant backgrounds, and exhibited decreased pharyngeal pumping and egg-laying. Wild-type SNCA crossed into eat-2(ad1113) does not significantly effect lifespan compared to that of the background strain. Pumping rate in wild-type SCNA and A53T SCNA overexpression mutants were less than control already at day 1 of adulthood. The attenuation of lifespan exptesion by SNCA overexpression by growing on thick bacterial lawns, suggests that DR may explain some fo the effects on lifespan. SCNA overexpression increases average lifespan by 21.3% (wild-type) and 16.3% (A53T) [16782295].
Mutation of SCNA (alias alpha synclein) is associated with Parkinson's disease [9197268], which is characterized with resting tremor, rigidity bradykinesia and posural instability that are associated with selective neurodegeneration of the pigmented neurons in the brain stem (substantia nigra and locus coerues) and the presence of intracytoplasmic inclusion bodies (Lewy bodies) [Yamamura et al. 1973]. The mutated protein (Ala53Thr or Ala30Pro) may misfold, aggregate and resist degradation [11433374].SNCA was found to be associated with longevity [22912757]. SNCA was not found to be associated with longevity [22912757]. | Human |
| TOX | thymocyte selection-associated high mobility group box | TOX was found to be associated with longevity [22279548]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | TNFSF8 was found to be associated with longevity [22279548]. | Human |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | TNFRSF11A was found to be associated with longevity [22279548]. | Human |
| TNFb | tumor necrosis factor | TNFb was found to be associated with longevity [17989723]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| Tmem218 | Transmembrane protein 218 | Tmem218 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TMEM2 | transmembrane protein 2 | TMEM2 was found to be associated with longevity [22279548]. | Human |
| Thrsp | Thyroid hormone-inducible hepatic protein | Thrsp is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| THO, mtDNA | THO complex 1 | THO, mtDNA was found to be associated with longevity [11053670]. | Human |
| THO | THO complex 1 | THO was found to be associated with longevity [9887369]. | Human |
| SIRT3 | sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) | The TT genotype of a silent G/T transition (G477T) in the SIRT3 gene was found to be correlated with longevity in males (but not females) in a study of individuals from Calabria, Italy [14580859]. | Human |
| SOD2 | superoxide dismutase 2, mitochondrial | The SOD2 rs2758331 has been correlated with exceptional longevity in a plethora of genetic signatures [22279548].SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [17903295]. SOD2 was found to be associated with longevity [15621215]. SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [19428448]. SOD2 was not found to be associated with longevity [9887369]. SOD2 was found to be associated with longevity [22279548]. SOD2 was not found to be associated with longevity [24163049]. | Human |
