| BNA6 | Biosynthesis of Nicotinic Acid 6 | Deletion of BNA6 (alias QPT1) has no effect on replicative lifespan and is not required for lifespan extension by DR, but is lethal with mutation of NPT1 [11000115]. Deletion of BNA6 decreases chronological lifespan [17110466]. | Nematode |
| mec-1 | MEChanosensory abnormality 1 | Loss of function mutations in mec-1 do not effect lifespan [2428682]. mec-1 mutants are touch insenstive, lethargic, and have displacement of some microtubule cells and amphidial neurons as well as defective fasciculation [2428682]. | Nematode |
| ins-22 | INSulin related 22 | RNAi of ins-22 has no effect on lifespan. ins-22 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| fog-3 | Feminization Of Germline 3 | The fog-3(q470) allele has no effect on lifespan [11799246]. In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [7713418]. | Nematode |
| fog-2 | Feminization Of Germline 2 | fog-2(q71) allele has no effect on lifespan [10747056]. fog-2 mutant display hermaphrodite specific germ line feminization [11076749]. | Nematode |
| fog-1 | Feminization Of Germline | The fog-1(q180) allele has no effect on lifespan [11799246]. fog-1 mutants are sterile and make oocytes but not sperm [2341035]. | Nematode |
| fem-3 | FEMinization of XX and XO animals | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Nematode |
| eat-5 | EATing: abnormal pharyngeal pumping 5 | The eat-5(ad464) allele has no significant effect on lifespan [9789046], although it displays defects in pharyngeal feeding behaviour [8462849]. | Nematode |
| eat-10 | EATing: abnormal pharyngeal pumping 10 | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Nematode |
| daz-1 | human DAZ (Deleted in Azoospermia) homolog | Mutation of daz-1 has no effect on lifespan [11799246]. daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [10662646]. Although sperm production is normal, oocytes precursors arrest at meiotic prophase and undergo apoptosis | Nematode |
| uba-1 | UBA (human ubiquitin) related | Overexpression of uba-1 does not result in significant increase in median lifespan [22737090]. | Nematode |
| ucp-4 | UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) | Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090]. | Nematode |
| ctl-1 | CaTaLase 1 | ctl-1 loss of function shortens lifespan to 77% of wild-type animals. ctl-1 mutants accumulate fluorescent material faster than wild-type, indicating accelerated aging [12610632]. ctl-1 mutation prevents lifespan extension by daf-2 or clk-1. Mutation of ctl-1 reudces catalase activty by 50% [10335847].
All these results have been retracted. | Nematode |
| — | (-)-epidcatechin | Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. | Nematode |
| NAC | N-acetyl cysteine | Treatment with 10 mM of NAC has no effect on the lifespan of wild-type, but fully abolishes the increased longevity of nuo-6 and severly limits that of isp-1. At high concentration (> 10-15 nM) NAC can be become deleteroius even on the wild-type [21151885]. | Nematode |
| Vitamin C | — | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Nematode |
| rrf-1 | RNA-dependent RNA polymerase Family | Although rrf-1(pk1417) mutants seem to have elevated DAF-16 activity (as sod-3 transcript level is increased) the mean and maximum lifespan or ability to withstand elevated temperature is not different from wild-type [22574120]. | Nematode |
| aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | aak-1 does not appear to be required for the control of lifespan [15574588]. | Nematode |
| spg-7 | human SPG (spastic paraplegia) 7 | RNA interference of spg-7 in adulthood results in a 23% increase in mean lifespan [17411345]. | Nematode |
| sbds-1 | Shwachman-Bodian-Diamond Syndrome protein homolog 1 | RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. RNAi knockdown of sbds-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. SBDS-1 are elevated in eat-2 mutants. Increased content of SBDS-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| lars-2 | Leucyl Amino-acyl tRNA Synthetase | A mutation that impairs mitochondrial function was associated with a longer lifespan. Mutation of lrs-2/lars-2(mg312) extends lifespan and is associated with impaired mitochondrial function. The recessive allele mg312 of lars-2 extends lifespan by 200% at 20 degree Celsius and 30% at 25 degree Celsius. Lifespan extension by mg312 was not dependent on daf-16(mgDf47). Homozygous lars-2(mg312) worms had multiple pleotropies like lower rates of growth, pumping and defecation as well as remain the size of early L4 worms and are sterile, with an arrested gonad that exhibited no germ-cell differentiation lars-2 is ubiquitously express, with prominent expression in body-wall muscle and neurons, with a mitochondrial subcellular localisation. Mitochondria of lars-2 are noticeably disorganized, swollen and sometimes fused. lars-2 animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| fbxa-121 | F-box A protein | RNA interference of fbxa-121 in adulthood shortens the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts [17392428]. | Nematode |
| dod-19 | Downstream Of DAF-16 (regulated by DAF-16) | RNA interference of dod-19 extends lifespan by 28%. dod-19 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| daf-1 | abnormal DAuer Formation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Nematode |
