Hsp70Ba | Heat-shock-protein-70Ba | Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% [19420297].
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762]. | Fruit fly |
CG34243 | — | CG34243 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
fry | furry | fry exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
CG16718 | — | CG16718 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
CG6195 | — | CG6195 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
CG6184 | — | CG6184 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
endoA | endophilin A | endoA exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
Rh2 | Rhodopsin 2 | Rh2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG12576 | — | CG12576 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG32022 | — | CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG4942 | — | CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG16711 | — | CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
LanB2 | Laminin B2 | LanB2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
kst | karst | kst exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it has three differentially expressed transcripts in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG12016 | — | CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
dro4 | drosomycin-4 | dro4 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
dro2 | drosomycin-2 | dro2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
CG13917 | — | CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
CG7852 | — | CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
CG12090 | — | CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
Psa | Puromycin sensitive aminopeptidase | Psa exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages except 50 days [23106705]. Experimental u-regulation of Psa protects against tau-induced neurodegeneration [16950154]. | Fruit fly |
Tequila | — | Tequila exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Tequila is upregulated with age and microbial infection, while downregulated with oxidative stress [11095759; 17196240; 15475297].
| Fruit fly |
Doc1 | — | Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705].
| Fruit fly |
CG5194 | — | CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
Doc3 | Dorsocross3 | Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596].
| Fruit fly |