Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
2 Downregulation of exo-3 6239 Schlotterer et al., 2010 20346071 Whole body Age — — — —
39 AMP/ATP increases 6239 Apfeld et al., 2004 15574588 whole body Age 4 day 18 day Hemaphrodite AMP/ATP ratio in living animals increases from <0.1 at day 4 of adulthood to 0.8 at day 18 (an age near the maximum lifespan of the population). Linear regression indicates a strong correlation between AMP/ATP ratio and life expectancy.
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
61 Loss of protein homeostasis 6239 — 22103665 whole body — 1 day 11 day hermaphrodites Loss in protein homeostasis during aging may lead to impaird protein solubility and cellular dysfunction [22103665].
62 Fertility declines 6239 — 20041217 whole body age — — females Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217].
63 Fertility declines 9606 20041217 — whole body age — — females Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217].
57 White matter integrity decreases 9606 Samanez-Larkin et al., 2012 22496578 white matter age 21 year 85 year males/females Older age is associated with decreased reward learning and decreased white matter integrity in specific pathways running form the thalamus to the medial prefrontal cortex and from the meial prefrontal cortex to the ventral stratium
59 Deteriorarition of circadian rhytms 10090 Farajnia, et al 2012 — Suprachiasmatic Nucleus age 2 month 30 month — Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuron’s rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm.
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
51 DHEA increases 9606 Willcox et al., 2007 17986602 serum diet Okinawa — — Okinawa aged 65-plus have relatively high DHEA levels.
52 DHEA decreases 9606 Hinson and Raven, 1999 10495400 serum age 25 year 85 year males/females DHEAS (Dehydroepiandrosterone sulphate) is the most abundant circulating steroid secreted by adrenal glands. Duo to its position int the steroid cascade DHEA act like kind of ”the mother steroid” (Regelson et al., 1994). DHEA reaches its highest levels at age 20-24. Its serum concentration declines with increasing age after 25 years and diminishes about 95% by 85 years. DHEA deficiency syndrome is a new term for old age [10495400].
53 DHEA increases 9606 Hinson and Raven, 1999 10495400 serum age 10 year 20 year males/females DHEA reaches its highest levels at age 20-24 [10495400].
54 DHEA decreases 9544 Lane et al., 1997 9215277 serum Age 5 year 26 year males/females Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277].
55 DHEA deline slows 9544 Lane et al., 199 9215277 serum diet DR — males/females DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277].
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
92 SM(d18:1/12:0) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299].
93 Tetracosahexaenoic acid decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299].
94 7alpha-dihydroxy-4-cholesten-4-one decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of 7alpha-dihydroxy-4-cholesten-4-one decreases from 3 to 33 months [22661299].
3 HDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
4 HDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
5 HDL increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
6 VLDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
7 VLDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
8 VLDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
9 LDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
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