Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
1 | ROS production increases | 4932 | Laun et al., 2001 | 11251834 | — | Age | young | old | — | — |
43 | Follicle stimulating hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and emale | Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women. |
44 | Luteneinzing hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women. |
45 | human chorionic gonadotrophin increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | human chorionic gonadotrophin hCG increases in both men and women after age 40. |
46 | DHEA declines | 9606 | Jeff | — | — | — | 70 | — | male | — |
47 | Melatonin declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)). |
48 | Growth hormone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
49 | Progesterone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
50 | Vitamin D3 declines | 9606 | — | — | — | — | — | — | — | As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically. |
56 | Ability to make decisions in novel sitations decreases | 9606 | Samanez-Larkin et al., 2012 | 22496578 | — | age | 21 year | 85 year | males/females | The ability to make decisions in novel sitations decreases with age from 21 to 85 years [22496578]. |
65 | Protein expression variation increases | 4932 | Levy et al., 2012 | — | — | age | — | — | — | Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012]. |
66 | Tsl1 abundance increases | 4932 | Levy et al., 2012 | — | — | age | — | — | — | Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012]. |
68 | Increase in upper and central body fat deposition | 9606 | — | 2921472 | — | age | — | — | — | There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472]. |
71 | Telomere shortening | 10090 | — | 22585399 | — | age | — | — | — | Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880]. |
73 | p16 expression increases | 10090 | — | — | — | age | — | — | — | p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence. |
74 | Reduced regenerative capacity | — | — | — | — | — | — | — | — | Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569]. |
75 | Metabolic and mitochondrial decline | 10090 | — | 22585399 | — | age | — | — | males/females | 2 years old mice exhibit metabolic and mitochondrial decline [22585399]. |
76 | OSH5 upregulation | 4932 | Gebre et al. unpublished | — | — | age | — | — | — | OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished]. |
77 | Osh6 downregulation | — | Gebre et al., unpublished | — | — | age | — | — | — | Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished]. |
78 | Sir2 decline | 4932 | — | 21436897 | — | age | — | — | — | Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897]. |
79 | Vacuolar membrane deteriorates | 4932 | — | 18690010 | — | age | — | — | — | The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010]. |
80 | Cisd2 expression declines | — | — | 22661501 | — | age | — | — | — | Cisd2 expression decreases with age [22661501]. |
81 | elt-5 expression increases | 6239 | 17608836 | 17608836 | — | age | — | — | — | Expression of elt-5 increases with during devleopment and aging [17608836]. |
82 | elt-6 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-6 increases during devleopment and aging [17608836]. |
83 | elt-3 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-3 increases during devleopment and aging [17608836]. |
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