Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
1 ROS production increases 4932 Laun et al., 2001 11251834 — Age young old — —
43 Follicle stimulating hormone increases 9606 Jeff — — Age 40 year — male and emale Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women.
44 Luteneinzing hormone increases 9606 Jeff — — Age 40 year — male and female Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women.
45 human chorionic gonadotrophin increases 9606 Jeff — — Age 40 year — male and female human chorionic gonadotrophin hCG increases in both men and women after age 40.
46 DHEA declines 9606 Jeff — — — 70 — male —
47 Melatonin declines 9606 — — — Age 70/35 year — male/female Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)).
48 Growth hormone declines 9606 — — — Age 70/35 year — male/female —
49 Progesterone declines 9606 — — — Age 70/35 year — male/female —
50 Vitamin D3 declines 9606 — — — — — — — As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically.
56 Ability to make decisions in novel sitations decreases 9606 Samanez-Larkin et al., 2012 22496578 — age 21 year 85 year males/females The ability to make decisions in novel sitations decreases with age from 21 to 85 years [22496578].
65 Protein expression variation increases 4932 Levy et al., 2012 — — age — — — Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 — — age — — — Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
68 Increase in upper and central body fat deposition 9606 — 2921472 — age — — — There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
71 Telomere shortening 10090 — 22585399 — age — — — Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity — — — — — — — — Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
75 Metabolic and mitochondrial decline 10090 — 22585399 — age — — males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
76 OSH5 upregulation 4932 Gebre et al. unpublished — — age — — — OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
77 Osh6 downregulation — Gebre et al., unpublished — — age — — — Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
78 Sir2 decline 4932 — 21436897 — age — — — Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
79 Vacuolar membrane deteriorates 4932 — 18690010 — age — — — The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
80 Cisd2 expression declines — — 22661501 — age — — — Cisd2 expression decreases with age [22661501].
81 elt-5 expression increases 6239 17608836 17608836 — age — — — Expression of elt-5 increases with during devleopment and aging [17608836].
82 elt-6 expression increases 6239 — 17608836 — age — — — Expression of elt-6 increases during devleopment and aging [17608836].
83 elt-3 expression increases 6239 — 17608836 — age — — — Expression of elt-3 increases during devleopment and aging [17608836].
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  • 25 of 129 Biological changes

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