Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
1 ROS production increases 4932 Laun et al., 2001 11251834 — Age young old — —
2 Downregulation of exo-3 6239 Schlotterer et al., 2010 20346071 Whole body Age — — — —
38 HDL increases 9606 Fontana et al., 2004 15096581 Plasma Diet Chronic DR — — —
41 Mitochondrial dysfunction increases 9606 Petersen et al., 2003 12750520 muscle Age — — — Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520].
50 Vitamin D3 declines 9606 — — — — — — — As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically.
51 DHEA increases 9606 Willcox et al., 2007 17986602 serum diet Okinawa — — Okinawa aged 65-plus have relatively high DHEA levels.
59 Deteriorarition of circadian rhytms 10090 Farajnia, et al 2012 — Suprachiasmatic Nucleus age 2 month 30 month — Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuron’s rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm.
65 Protein expression variation increases 4932 Levy et al., 2012 — — age — — — Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 — — age — — — Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
68 Increase in upper and central body fat deposition 9606 — 2921472 — age — — — There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
70 IGF1 levels decline 9606 — 3322823 plasma age — — — A decline in IGF1 expression occurs with age progression. Levels of circulating IGF1 in humans are low at birth, rise progressively during childhood and peak during midadolescence, and then progressively fall as a function of age. Reduction in levels of circulating IGR1 is related to decreased secretion of growth hormone [3322823].
71 Telomere shortening 10090 — 22585399 — age — — — Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
72 IGF2 level changes 9606 — 3322823 plasma age — — — Circulating IGF2 reaches “adult” levels early in childhood, and changes are relatively small as a function of increasing age [3322823].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity — — — — — — — — Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
76 OSH5 upregulation 4932 Gebre et al. unpublished — — age — — — OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
77 Osh6 downregulation — Gebre et al., unpublished — — age — — — Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
78 Sir2 decline 4932 — 21436897 — age — — — Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
79 Vacuolar membrane deteriorates 4932 — 18690010 — age — — — The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
80 Cisd2 expression declines — — 22661501 — age — — — Cisd2 expression decreases with age [22661501].
81 elt-5 expression increases 6239 17608836 17608836 — age — — — Expression of elt-5 increases with during devleopment and aging [17608836].
82 elt-6 expression increases 6239 — 17608836 — age — — — Expression of elt-6 increases during devleopment and aging [17608836].
83 elt-3 expression increases 6239 — 17608836 — age — — — Expression of elt-3 increases during devleopment and aging [17608836].
84 Cell proliferation increases 1016 11744049 — — Diet — — — 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
  • Page 1 of 6
  • 25 of 129 Biological changes

Add change

Comment on This Data Unit