Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
| ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
|---|---|---|---|---|---|---|---|---|---|---|
| 110 | Yef3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Yef3 levels [Herbert et al. in press]. |
| 57 | White matter integrity decreases | 9606 | Samanez-Larkin et al., 2012 | 22496578 | white matter | age | 21 year | 85 year | males/females | Older age is associated with decreased reward learning and decreased white matter integrity in specific pathways running form the thalamus to the medial prefrontal cortex and from the meial prefrontal cortex to the ventral stratium |
| 6 | VLDL decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
| 7 | VLDL decrease | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 8 | VLDL decrease | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
| 50 | Vitamin D3 declines | 9606 | — | — | — | — | — | — | — | As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically. |
| 11 | Valine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
| 79 | Vacuolar membrane deteriorates | 4932 | — | 18690010 | — | age | — | — | — | The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010]. |
| 66 | Tsl1 abundance increases | 4932 | Levy et al., 2012 | — | — | age | — | — | — | Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012]. |
| 33 | Trimethylamine-N-Oxide increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
| 26 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
| 27 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 28 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
| 93 | Tetracosahexaenoic acid decrease | 10090 | — | 22661299 | serum | age | 3 months | 22 months | female | Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299]. |
| 71 | Telomere shortening | 10090 | — | 22585399 | — | age | — | — | — | Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880]. |
| 88 | Structural chromosome variation | 9606 | — | — | — | — | — | — | — | Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012]. |
| 121 | Smaller body size | 6239 | — | 22810224 | — | mutation | eat-2 | wild-type | — | eat-2 mutants are noticeable smaller than wild-type [22810224]. |
| 92 | SM(d18:1/12:0) decrease | 10090 | — | 22661299 | serum | age | 3 months | 22 months | female | Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299]. |
| 78 | Sir2 decline | 4932 | — | 21436897 | — | age | — | — | — | Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897]. |
| 98 | Shift in metabolism towards increasing fatty acid syntheses and breakdown | 7227 | Katewa et al. 2012 | — | muscle | diet | DR (0.5% yeast extract) | AL (5% yeast extract) | female/male | Flies on DR shift their metabolism toward increasing fatty acid synthesis and breakdown, specifically in muscle tissues, which is required for varoius responses to DR [22768842]. |
| 34 | Scyllo-inositol increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
| 109 | Sbp1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Sbp1 levels [Herbert et al. in press]. |
| 107 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Rtc3 levels [Herbert et al. in press]. |
| 118 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Rtc3 levels [Herbert et al. in press]. |
| 1 | ROS production increases | 4932 | Laun et al., 2001 | 11251834 | — | Age | young | old | — | — |
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