Denigma

Clonal amplification of mutant mtDNA causes PM cell or skeletal muscle fiber segment to become anaerobic -blue-> Reductive Hotspot: Anaerobic cells & muscle fiber segments export electrons through plasma membrane, generating extracellular ROS

Clonal amplification of mutant mtDNA causes PM cell or skeletal muscle fiber segment to become anaerobic

 4 light blue light blue

blue

 narrow No

Reductive Hotspot: Anaerobic cells & muscle fiber segments export electrons through plasma membrane, generating extracellular ROS

 2 red yellow brown