Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (30)   No Age Effect (8)  
  • Study type: + -
    Meta‑Analysis « 
  • Variant type: + -
    SNP (37)   Haplotype (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1799752 ACE 1.25 0.032 1803 vs 10484 — Multiethnic Centenarian — DD Meta-Analysis 23623925
    rs1799752 ACE 1.16 0.001 1803 vs 10484 — Multiethnic Centenarian — D Meta-Analysis 23623925
    rs17702471 GPC6 1.81 8.33e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.72 4.94e-06 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.81 8.97e-05 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1456669 — 0.78 9.89e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1456669 — 0.82 0.000312 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs13220810 FOXO3A — 1.0 1746 vs 1219 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs13217795 FOXO3A 1.27 0.001 1706 vs 1481 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs11954180 SLC6A7 1.30 0.001639 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs11218921 — 0.59 5.47e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1042663 C2 0.72 8.39e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1016013 — 1.21 2.87e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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