Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2075650 APOE — 0.000527 1364 — American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
    rs978739 TAS2R16 0.62 0.001 348 vs 593 — Calabrian Mean age 93.82 non-AA AA Candidate Region/Gene 23133589
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs10047589 TXNRD1 1.46 0.043 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G — Candidate Region/Gene 22406557
    rs1008438 HSPA1A 3.86 0.016 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    rs1008438 HSPA1A — 0.02 894 total — Italian 18-109 C A (applies to males) Candidate Region/Gene 16896546
    rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs10149689 TSHR 1.22 0.08 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1042522 TP53 0.88 0.005 9219 participants (Copenhagen City Heart Study) — Danish Range: 20-95 G — Candidate Region/Gene 18256523
    rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
    rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
    rs1059234 CDKN1A 0.47 0.026 184 vs 184 — Italian 100 T C Candidate Region/Gene 20126416
    rs1061170 CFH 1.78 0.005 491 with follow-up during 4 years — Finn >90 — TT Candidate Region/Gene 19000922
    rs1061581 HSPA1B — 0.05 191 vs 53 — Chinese >90 A G Candidate Region/Gene 19840767
    rs1061581 HSPA1B 2.76 0.039 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs10737170 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs11039149 NR1H3 — 0.015 599 — Dutch 85 years haplotype 1 haplotype 2 Candidate Region/Gene 17452725
    rs1137100 LEPR — 0.026 128 vs 414 — Polish 100+ AA — Candidate Region/Gene 24549597
    rs11555236 SIRT3 — 0.03 357 — Italian 70+ — T Candidate Region/Gene 23839864
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs11578696 LMNA — 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
    rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
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    • 25 of 153 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue