Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOA1-MspI-RFLP (−75) APOA1 — 0.016 229 vs 571 — Calabrian 81–109 (median 101) A (=Absence) — Candidate Region/Gene 12556235
    rs2764264 FOXO3 — 0.0002 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs13217795 FOXO3 — 0.0006 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2802292 FOXO3 — 0.0001 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2866164 MTTP — 0.05 126 vs 288 — Ashkenazi Jewish median age = 97 CG/GG — Candidate Region/Gene 22496539
    rs282070 MAP3K7 — 0.0011 288 vs 554 — Calabrian 90+, median 92 G — Candidate Region/Gene 22576335
    rs2111699 GSTZ1 — 0.0014 288 vs 554 — Calabrian 90+, median 92 A — Candidate Region/Gene 22576335
    rs10014396 SNCA — 0.021 769 total (see notes) — Caucasian >90 (oldest age group) C — Candidate Region/Gene 22912757
    rs3775439 SNCA — 0.025 769 total (see notes) — Caucasian >90 (oldest age group) A — Candidate Region/Gene 22912757
    rs1042522 TP53 — 0.006 503 vs 569 — Italian >81 R — Candidate Region/Gene 23125046
    rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs1974676 Intergenic — 0.00496 1173 vs 570 — American 85-100 — G Genome-Wide Association Study 22533364
    rs1834497 CLSTN2 — 0.00979 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
    rs2590504 KIAA0649 — 0.00854 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs2024714 CDH4 — 7.43e-05 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs41383 NLRC5 — 0.00455 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs16975963 Noncoding — 0.00713 1173 vs 570 — American 85-100 — G Genome-Wide Association Study 22533364
    rs13008689 Intergenic — 0.00686 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
    rs3120819 Intergenic — 0.00806 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs9876781 Noncoding — 0.000868 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
    rs9517320 STK24 — 0.00204 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs139170 PARVG — 0.00332 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs4648884 RUNX3 — 0.00992 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs739401 CARS — 0.00154 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    rs10256972 C7orf50 — 0.00224 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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