Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (84)   No Age Effect (161)  
  • Study type: + -
    ‑ (14)   Candidate Region/Gene (180)   Genome‑Wide Association Study (67)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
    SNP (157)   Haplotype (23)   Other (1)   STR (1)   Deletion (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
    192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
    ?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
    ?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
    rs854560 PON1 — 1.0 579 vs 308 — Italian Over 100 — — Candidate Region/Gene 12082503
    codon 192 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
    codon 55 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
    Not specified REN — 0.029 157 vs 218 — Italian Centenarians 11 — Candidate Region/Gene 15105583
    Not specified IL2 — 0.05 470 vs 120 — Italian, Bulgarian Age range: 65-99 — — Candidate Region/Gene 21299522
    Not specified IFNG — 0.05 707 vs 339 — Turkish, Polish, Italian, Bulgarian Age range: 65-99 — — Candidate Region/Gene 21299522
    - HRAS1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes — — - 19367319
    - SIRT3 — 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - TH — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - INS — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - IGF2 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4073591 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4073590 DEAF1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs11040489 KRTAP5-6 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4930001 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs800140 TSPAN32 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs16928120 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs189037 ATM 1.85 0.028 128 vs 150 — Italian — — — - 22960875
    VNTR (Variable Number of Tandem Repeats) APOB — 0.003 143 vs 158 — Italian mean age is 102 years 35 or more tandem repeats — Candidate Region/Gene 9050915
    - TH — 0.045 202 vs 170 vs 82 — Italian 100-105 (oldest of 3 age groups, see notes) — — Candidate Region/Gene 11053670
    • Page 1 of 11
    • 25 of 263 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue