Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    No Age Effect « 
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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4930001 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs800140 TSPAN32 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs16928120 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    Cdx2-GATA haplotype 1 allele Vitamin D receptor — 0.78 935 participants — Dutch mean age = 75.7 years — — Candidate Region/Gene 21051524
    I/D (insertion/deletion) ACE — 0.33 560 vs 560 — French centenarians 100th year or beyond, mean age 103.1 — — Candidate Region/Gene 11280044
    -670A/G FAS — 0.608 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    -1377G/A FAS — 0.106 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    IVS2nt-124 FASLG — 0.315 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    IVS3nt-167 FASLG — 0.462 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
    rs147610191 APOA4 — 0.05 229 vs 571 — Calabrian 81–109 (median 101) — — Candidate Region/Gene 12556235
    - GSTM1 — 0.54 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    Presence/Deletion GSTT1 — 0.2 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    Msp1 CYP1A1 — 0.19 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    Msp1 restriction fragment length polymorphism in intron 6 (G/A) TP53 — 0.65 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    rs1042522 TP53 — 0.85 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    16 bp duplication in intron 3 (WT=no duplicaiton) TP53 — 0.59 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    rs2071069 TPI1 — 0.05 1422 vs 967 — German mean age: 98.8, age range: 95–110 (SNP is G/A) — Candidate Region/Gene 18510744
    rs2071065 TPI1 — 0.05 1422 vs 967 — German mean age: 98.8, age range: 95–110 (SNP is T/C) — Candidate Region/Gene 18510744
    rs1063539 ADIPOQ10 — 0.2 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs182052 ADIPOQ10 — 0.22 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs266729 ADIPOQ10 — 0.08 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs2755209 FOXO1 — 0.48 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs2721069 FOXO1 — 0.62 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs2755213 FOXO1 — 0.77 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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