Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    e4 APOE 0.55 0.03 163 vs 1039 Spanish 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 Italian 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.35 0.001 729 vs 498 Japanese 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.04 376 vs 376 Canadian 85+ e4 Candidate Region/Gene 24126160
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    LPA isoform LPA 0.05 84 (cases) vs 517 Japanese 80+ Lp(a)F, Lp(a)B Candidate Region/Gene 11269751
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    HP*1 F/S HP 0.82 0.33 1072 total Italian >88 Candidate Region/Gene 21147083
    rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
    HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
    Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
    A-3826G (rs1800592) - C-3740A UCP1 0.81 0.014 236 vs 741 Italian >91 G-A Candidate Region/Gene 21827845
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A 0.9852 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A 0.1761 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A 0.1282 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A 0.8 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A 0.1856 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A 0.139 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    C4B1 C4B 0.05 77 (cases) vs 235 Italian Mean age 101 Candidate Region/Gene 10219002
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs699947-(−1190G/A)-rs1570360-(−634G/C) VEGFA 0.03 332 vs 648 Italian 85-99 (mean 89.8±2.8) non A-A-G-G haplotypes A-A-G-G Candidate Region/Gene 17574707
    rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
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    • 25 of 53 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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