Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (243)   No Age Effect (314)  
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (375)   Meta‑Analysis (37)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (147)   Mitochondrial Haplogroup (1)   Mitochondrial genome (3)  
  • Variant type: + -
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs10047589 TXNRD1 1.46 0.043 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G — Candidate Region/Gene 22406557
    rs207444 XDH — 0.046 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G - Unsure — Candidate Region/Gene 22406557
    rs26802 GHRL 2.34 0.032 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    rs13320360 MLH1 3.13 0.0036 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    rs2509049 H2AFX 0.63 0.017 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    rs705649 XRCC5 — 0.029 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A - Unsure — Candidate Region/Gene 22406557
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs2267723 GHRHR 0.70 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old C A Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs13251813 WRN 1.84 0.0002 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1805329 RAD23B 0.72 0.0309 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs2953983 POLB 1.60 0.0225 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 C — Candidate Region/Gene 22406557
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A — Candidate Region/Gene 22406557
    rs2267723 GHRHR 0.70 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) G — Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A — Candidate Region/Gene 22406557
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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