Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (10)   No Age Effect (49)  
  • Study type: + -
    Candidate Region/Gene (59)   Complete Mitochondrial Genome (1)  
  • Variant type: + -
    SNP (33)   Haplotype (3)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    HMOX1 (GT)_n repeats HMOX1 0.56 0.0027 108 vs 154 — Japanese Mean age 80.5 33 < repeats — Candidate Region/Gene 12566526
    D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3779501 PIK3CG — 0.139 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745546 INSR — 0.168 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs1799817 INSR — 0.205 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2288404 INSR — 0.277 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs1801278 IRS1 — 0.337 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2305268 PIK3CB — 0.363 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2297627 FOXO1A — 0.495 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2297626 FOXO1A — 0.512 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs1801123 IRS1 — 0.774 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs361072 PIK3CB — 0.829 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3751436 FOXO1A — 0.369 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs7914 CBL — 0.69 190 vs 376 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs738288 ATF4 — 0.54 205 vs 396 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs6519194 ATF4 — 0.41 206 vs 397 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs1776180 EXO1 — 0.16 206 vs 401 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs2249466 CBL — 0.9 207 vs 394 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs2999131 — — 0.31 208 vs 391 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs1048310 — — 0.87 208 vs 399 — Japanese 95+ — — Candidate Region/Gene 23770741
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    • 25 of 61 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue