Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (84)   No Age Effect (161)  
  • Study type: + -
    ‑ (14)   Candidate Region/Gene (180)   Genome‑Wide Association Study (67)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
    SNP (157)   Haplotype (23)   Other (1)   STR (1)   Deletion (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination — 3.19 0.0006 208 vs 514 — Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    rs4073591 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4930001 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs16928120 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs16928120 — — 0.00057 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    S61712.1 (GenBank, 3` VNTR) — — 0.003 143 (51 m, 92 f) vs 158 (77 m, 81 f) — Italian 102 +/- 2 <35 repeats — Candidate Region/Gene 9050915
    rs4291539 — 1.81 4.41e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10923806 — 2.30 7.24e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs6540664 — 1.46 9e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs12088486 — 0.56 1.75e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10514626 — 0.38 1.12e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1562688 — 0.50 4.93e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs6769400 — 1.91 1.99e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2670104 — 0.67 6.21e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10513702 — 1.85 4.53e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2354314 — 0.51 7.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4282145 — 0.38 5.32e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs11738302 — 0.57 6.89e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1428689 — 1.85 5.51e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs9366292 — 0.64 8.65e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1563301 — 0.50 2.36e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10277343 — 0.64 3.88e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4727899 — 0.55 7.83e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs846427 — 1.94 3.82e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    • Page 1 of 11
    • 25 of 263 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue