Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (153)   Meta‑Analysis (30)   Genome‑Wide Association Study (50)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4918255 SORCS1 1.21 8.81e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1822590 — 1.21 7.57e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1867102 C9orf3 1.20 7.28e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs216148 CSF1R 0.75 6.36e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1016013 — 1.21 2.87e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs3803833 — 0.77 2.72e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.72 4.94e-06 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1800624 — — 0.028 28 vs 56 — Caucasian 90+ non-AA AA Candidate Region/Gene 24284407
    rs1137100 LEPR — 0.026 128 vs 414 — Polish 100+ AA — Candidate Region/Gene 24549597
    rs7799039 LEP — 0.048 128 vs 414 — Polish 100+ — GG Candidate Region/Gene 24549597
    rs2149954 — 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
    rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
    73G — — 0.0086 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    152C — — 0.004 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    8899A — — 0.0016 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    rs2075650 TOMM40 1.43 0.006 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs405509 APOE 1.18 0.027 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs395908 PVRL2 0.81 0.048 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs519825 PVRL2 1.28 0.01577 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs12978931 PVRL2 1.15 0.0445 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs7460 PTK2 0.40 0.001 175 vs 355 — Spanish 100-111 A T Candidate Region/Gene 24930376
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs2802288 FOXO3A 1.24 0.003 1688 vs 1214 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs1935949 FOXO3A 1.14 0.001 1435 vs 2098 — Multiethnic 90+ — — Meta-Analysis 25038186

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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