Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (10)   No Age Effect (49)  
  • Study type: + -
    Candidate Region/Gene (59)   Complete Mitochondrial Genome (1)  
  • Variant type: + -
    SNP (33)   Haplotype (3)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs7843014 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs7460 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs8051232 COQ7 — 0.9 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs2249466 CBL — 0.9 207 vs 394 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs1048310 — — 0.87 208 vs 399 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs7069102 SIRT1 — 0.84 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs361072 PIK3CB — 0.829 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs11217184 CBL — 0.8 212 vs 396 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs1801123 IRS1 — 0.774 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2755213 FOXO1 — 0.77 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs7192898 COQ7 — 0.73 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs1885472 SIRT1 — 0.71 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs7914 CBL — 0.69 190 vs 376 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs3753645 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
    rs3753644 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
    rs2721069 FOXO1 — 0.62 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs1333049 CDKN2B-AS1 — 0.602 742 vs 920 — Japanese 100 — — Candidate Region/Gene 24163049
    rs738288 ATF4 — 0.54 205 vs 396 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs1853432 JUN — 0.52 213 vs 398 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs2297626 FOXO1A — 0.512 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2297627 FOXO1A — 0.495 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2755209 FOXO1 — 0.48 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    • Page 1 of 3
    • 25 of 61 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue