Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (31)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (6)  
  • Variant type: + -
    Haplotype « 
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 — Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 — Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 — Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 — Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
    rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    A-3826G (rs1800592) - C-3740A UCP1 0.81 0.014 236 vs 741 — Italian >91 G-A — Candidate Region/Gene 21827845
    rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases — Danish Mean age 92.8 +/- 0.4 — G-C-T (haplotype) Candidate Region/Gene 20388090
    e4 APOE 0.55 0.03 163 vs 1039 — Spanish 100+ e4 — Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 — Italian 100+ e4 — Candidate Region/Gene 24534555
    mtDNA haplogroups mtDNA 0.40 0.0003 74 vs 187 — Amish >80 years J non-J Mitochondrial Haplogroup 21750925
    9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 — Chinese 90-100 years old J non-J - 18759861
    Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 — Italian >88 e4 e2 Candidate Region/Gene 21703254
    e4 APOE 0.35 0.001 729 vs 498 — Japanese 100+ e4 — Candidate Region/Gene 24534555
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    rs1800896 - rs1800629 IL10 — 0.038 174 vs 224 — Italian >100 — GG-GG (only in men) Candidate Region/Gene 12676903
    mtDNA haplogroups mtDNA — 0.027 138 — Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
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    • 25 of 39 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue