Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (153)   Locus (2)   Haplotype (31)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    192 PON1 1.26 0.007 Italian: 308 vs 579; Northern Irish: 296 vs 296 — Irish Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7 Q — Candidate Region/Gene 15050299
    rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish mean age 98.2 A — Candidate Region/Gene 16602826
    Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
    rs3928306 MT-RNR2 0.49 0.027 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
    rs28359172 MT-ND5 0.30 0.003 98 vs 117 — Chinese 90–100 G — Candidate Region/Gene 18759861
    rs73598374 ADA 0.32 0.0056 97 vs 261 — Italian >88 G*/G* A*+ Candidate Region/Gene 21865054
    GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
    - CYP1A — 0.68 94 vs 418 — Italian 100 years vs 46 years — — Candidate Region/Gene 11162685
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    rs1042522 TP53 0.88 0.005 9219 participants (Copenhagen City Heart Study) — Danish Range: 20-95 G — Candidate Region/Gene 18256523
    rs11235972 UCP3 — 0.029 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) — Danish 93 A — Candidate Region/Gene 22743239
    rs3781907 UCP3 — 0.05 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) — Danish 93 G — Candidate Region/Gene 22743239
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    rs1008438 HSPA1A — 0.02 894 total — Italian 18-109 C A (applies to males) Candidate Region/Gene 16896546
    rs189037 (genotype) ATM — 0.004 875 (280 m, 595 f) vs 886 (491 m, 395 f) — Chinese Mean age 94,6, healthy — CT (Article); GA (ENSEMBL) Candidate Region/Gene 20816691
    rs10737170 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs915179 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs2485662 LMNA — 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
    rs547915 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs582690 LMNA — 0.078 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs6686943 LMNA — 0.51 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs508641 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs12117552 LMNA — 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs4641 LMNA — 0.5 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs12063072 LMNA — 0.36 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    • Page 1 of 14
    • 25 of 344 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue