Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (607)   No Age Effect (103)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP (147)   Locus (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 — 0.044 303 — Human Minimum age 98 for one sibling (of sibship) — — Genome-Wide Association Study 11526246
    rs326146 ADCY2 1.46 0.024 137 vs 213 — Korean Mean age 90 — A Genome-Wide Association Study 19641380
    rs155979 PCSK1 0.61 0.012 137 vs 213 — Korean Mean age 90 G — Genome-Wide Association Study 19641380
    rs3811952, rs155979, rs3762985 — 0.54 0.008 137 vs 213 — Korean Mean age 90 CGA — Genome-Wide Association Study 19641380
    rs4237973 PIK3C2G 1.51 0.022 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
    rs1800802 MGP 0.77 0.132 137 vs 213 — Korean Mean age 90 C — Genome-Wide Association Study 19641380
    rs1054016 TNFSF11 1.09 0.579 137 vs 213 — Korean Mean age 90 T — Genome-Wide Association Study 19641380
    rs327519 PAX4 (for males) 5.70 0.004 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs712700 — 1.87 0.01 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs327512 — 5.55 0.005 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs1980042 LYN (for males) 2.10 0.006 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
    rs1979128 — 2.10 0.006 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs1450740, rs1450741, rs1562818, rs1980042, rs1027989, rs 1546518, rs3968371 — 3.72 0.002 137 vs 213 — Korean Mean age 90 — CTCCGCA Genome-Wide Association Study 19641380
    rs2274471 JAK2 (for males) 1.58 0.088 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
    rs671 ALDH2 (for males) 2.11 0.009 137 vs 213 — Korean Mean age 90 — A Genome-Wide Association Study 19641380
    rs2030071 IL12RB2 (for females) 0.18 0.008 137 vs 213 — Korean Mean age 90 T — Genome-Wide Association Study 19641380
    rs2072454, rs2293347, rs3807362, rs884225 EGFR (for females) 4.11 0.003 137 vs 213 — Korean Mean age 90 — CGCA Genome-Wide Association Study 19641380
    3p24.2–22.3 — — 0.037 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
    9q31.3–34.2 — — 0.054 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
    rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
    Q/H 95, rs2866164 — — 0.0005 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 Q95 G — Genome-Wide Association Study 14615589
    rs752766 Intergenic — 0.0058 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 — — Genome-Wide Association Study 14615589
    rs951085 Intergenic — 0.0041 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 — — Genome-Wide Association Study 14615589
    rs750032 PPP3CA — 0.0029 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 — — Genome-Wide Association Study 14615589
    rs1553432 Intergenic (upstream of C4orf17) — 0.0005 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 — — Genome-Wide Association Study 14615589
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    • 25 of 710 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue