Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (2)   No Age Effect (3)  
  • Study type: + -
    Candidate Region/Gene (9)  
  • Variant type: + -
    Deletion (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1799752 ACE — 0.016 12 vs 190 vs 105 — Greek 99-111 D I Candidate Region/Gene 23389097
    apoE haplotypes — — 0.02 80 vs 391 — Greek 80+ Apo e4 — Candidate Region/Gene 17234815
    APOE polymorphism APOE — 0.02 80 vs 391 — Greek >80 epsilon4 — Candidate Region/Gene 17234815
    I carriers of ACE — — 0.045 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    CHIT1 24-bp duplication CHIT1 — 0.05 129 vs 129 29 versus 129 Tunisian, Greek, Italian Mean age 97.6 Absence of duplication Presence of duplication Candidate Region/Gene 19881466
    rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs28362491 NFkB — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
    • 9 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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