Denigma

Longevity Variant Database

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  • Variant effect: + -
    No Age Effect « 
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    ‑ (1)   Candidate Region/Gene (33)   Mitochondrial Haplogroup (26)  
  • Variant type: + -
    SNP (17)   Haplotype (29)   STR (3)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    SI000565Q APOB — 0.001 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 — LL Candidate Region/Gene 17393087
    rs11279109 - APOB XbaI APOB — 0.001 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 — D - X+ Candidate Region/Gene 17393087
    rs189037 ATM — 0.004 875 vs 886 — Chinese mean 94.6 — CT Candidate Region/Gene 20816691
    APOB XbaI − SI000565Q APOB — 0.006 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
    VNTR DC-SIGNR — 0.041 361 vs 342 — Chinese >90 non-6/7 genotype 6/7 genotype Candidate Region/Gene 20003397
    rs11279109 - APOB XbaI - SI000565Q APOB — 0.044 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    mt5178A ND2 — 0.05 95 vs 105 — Chinese Mean age 76 — АА Candidate Region/Gene 12384792
    rs11279109 - SI000565Q APOB — 0.05 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    rs708272 CETP — 0.068 523 vs 498 — Chinese Mean age 93.4 — — Candidate Region/Gene 22336474
    15235G,8584A,9bp-deletion,10873T mtDNA — 0.086 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5465C,9bp-deletion,10873T mtDNA — 0.105 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    8584A,9bp-deletion,10873T mtDNA — 0.117 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs2053044 ADRB2 — 0.138 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    3010A,5178A,10400T mtDNA — 0.141 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    3970T,12705C,10873T mtDNA — 0.147 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1042713 ADRB2 — 0.149 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs5749998 MAPK1 — 0.152 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    7600A,4833G,14569A,10400T mtDNA — 0.153 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1892848 MAPK1 — 0.218 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs5999521 MAPK1 — 0.218 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs2853826 MT-ND3 — 0.219 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
    rs9861425 ADCY5 — 0.251 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    1736G,10873T mtDNA — 0.288 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12406A,3970T,12705C,10873T mtDNA — 0.304 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    9bp-deletion,10873T mtDNA — 0.311 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
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    • 25 of 60 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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