Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    ‑ (2)   Candidate Region/Gene (81)   Genome‑Wide Association Study (1)  
  • Variant type: + -
    SNP (36)   Haplotype (12)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 — Italian Centenarians M, S Z Candidate Region/Gene 17048073
    rs10491334 CAMK4 0.55 5.29e-05 410 vs 553 116 vs 160 Italian 90–109 — — Genome-Wide Association Study 21612516
    VNTR in intron 5 (DeltaEF1 site) SIRT3 — 8e-05 242 vs 703 — Italian Median age 102 2b — Candidate Region/Gene 15676284
    --1082G-->A IL10 — 0.0001 109 (oldest old men) vs 263 (healthy controls) — Italian >95 A — Candidate Region/Gene 15466015
    rs8052394 MT1a 2.16 0.0002 151 vs 100 — Italian Mean age 91.4 +/- 4.1 — A Candidate Region/Gene 16955215
    rs1805097 IRS2 2.03 0.0003 144 vs 418 — Italian 85-100 years old non-AA AA Candidate Region/Gene 19887537
    rs1800896 IL-10 3.00 0.0003 142 vs 153 — Italian Mean age 67 AA GG Candidate Region/Gene 15466015
    rs16928120 — — 0.00057 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination — 3.19 0.0006 208 vs 514 — Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 — Italian centenarians a3 allele (see notes) — Candidate Region/Gene 11943467
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 — Italian >88 e4 e2 Candidate Region/Gene 21703254
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.00211 184 vs 184 — Italian 100 non G-G-G-C-C-G haplotypes G-G-G-C-C-G Candidate Region/Gene 20126416
    rs4073591 DEAF1 — 0.002618 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
    VNTR (Variable Number of Tandem Repeats) APOB — 0.003 143 vs 158 — Italian mean age is 102 years 35 or more tandem repeats — Candidate Region/Gene 9050915
    S61712.1 (GenBank, 3` VNTR) — — 0.003 143 (51 m, 92 f) vs 158 (77 m, 81 f) — Italian 102 +/- 2 <35 repeats — Candidate Region/Gene 9050915
    rs1764391 GJA4 — 0.0035 56 vs 196 (males) — Italian >99 — CC Candidate Region/Gene 16970956
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.00394 184 vs 184 — Italian 100 non G-G-G-C haplotypes G-G-G-C Candidate Region/Gene 20126416
    rs4073590 DEAF1 — 0.004259 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    (A/C)−110 HSP70-1 0.40 0.005 120 vs 471 — Italian 100 years and above A — Candidate Region/Gene 14501185
    rs73598374 ADA 0.32 0.0056 97 vs 261 — Italian >88 G*/G* A*+ Candidate Region/Gene 21865054
    rs11040489 KRTAP5-6 — 0.005869 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+ (very old), 73-91 (old) G C Candidate Region/Gene 23125046
    rs1042522 TP53 — 0.006 503 vs 569 — Italian >81 R — Candidate Region/Gene 23125046
    rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
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    • 25 of 84 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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