Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    (A/C)−110 HSP70-1 0.40 0.005 120 vs 471 — Italian 100 years and above A — Candidate Region/Gene 14501185
    -308G/A TNF 0.33 0.001 71 vs 99 — Mexican 86.2 G — Candidate Region/Gene 16269080
    -351A/G ESR1 — 0.05 148 vs 414 — Polish 99.6-107.2; mean= 101.1±1.2 — — Candidate Region/Gene 20599431
    -397T/C ESR1 — 0.06 149 vs 414 — Polish 99.6-107.2; mean= 101.1±1.3 — — Candidate Region/Gene 20599431
    2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
    ?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
    ?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
    C4B1 C4B — 0.05 77 (cases) vs 235 — Italian Mean age 101 — — Candidate Region/Gene 10219002
    DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    FOXO3A, various FOXO3 1.67 0.0002 760 vs 1060 — Chinese 100+ — — Candidate Region/Gene 20884733
    H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    HLA DRB1*18 HLA-DRB1 — 0.0266 77 vs 299 — 100 — — Candidate Region/Gene 20426625
    HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 — Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
    HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 — Chinese >93 Cw3, Cw6. Cw7 — Candidate Region/Gene 9147371
    HLA-DQA1 haplotypes HLA-DQA1 — 0.04 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*0101=0104 alleles HLA-DQA1*0101=0104 Candidate Region/Gene 9389323
    HLA-DQA1 haplotypes HLA-DQA1 — 0.038 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*05 alleles HLA-DQA1*05 Candidate Region/Gene 9389323
    HLA-DQB1 haplotypes HLA-DQB1 — 0.0002 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-DQB1*0503 alleles DQB1*0503 Candidate Region/Gene 9389323
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 2.03 0.001 336 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR11 alleles DR11 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.46 0.01 488 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR13 alleles DR13 Candidate Region/Gene 9425225
    HLA-DRB1 haplotypes HLA-DRB1 — 0.004 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-DRB1*0401 alleles DRB1*0401 Candidate Region/Gene 9389323
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    • 25 of 121 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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