Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

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  • Variant effect: + -
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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs795602 MGST2 0.67 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1800591-rs61733139 MTTP — 0.46 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    rs61733139 MTTP — 0.43 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    rs1800591 MTTP — 0.64 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    rs2583988 SNCA — 0.26 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619363 SNCA — 0.24 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2301135 SNCA — 0.79 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619362 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619361 SNCA — 0.26 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs1372520 SNCA — 0.22 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3756063 SNCA — 0.54 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs1372519 SNCA — 0.19 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737012 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2583959 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs9995651 SNCA — 0.98 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737033 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3796661 SNCA — 0.59 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2572324 SNCA — 0.41 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2736990 SNCA — 0.31 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3775423 SNCA — 0.9 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs17180453 SNCA — 0.63 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs356218 SNCA — 0.53 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    -330T/G IL2 1.43 0.096 168 vs 214 — Italian >99 — — Candidate Region/Gene 16518704
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
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    • 25 of 35 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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