Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (50)   No Age Effect (97)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP « 
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs970048 Intergenic 1.77 7.17e-07 3746 vs 5912 — Dutch Mean age 94 — G Genome-Wide Association Study 21418511
    rs12740413 ARHGEF19 — 1.3e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs12562047 UCK2 — 2.7e-05 1364 — American, British Age range 50-108; mean age at death 80.2 A C Genome-Wide Association Study 22445811
    rs6701445 TAF5L 1.84 4.19e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1538287 KCNH1 0.55 4.87e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2495513 TMEM61 0.60 8.13e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    • 6 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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