Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
    E2 / E3 / E4 APOE — 1.2e-08 560 vs 560 — French centenarians 100th year or beyond, mean age 103.1 E4 — Candidate Region/Gene 11280044
    rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 — Genome-Wide Association Study 21418511
    rs429358, rs7412 APOE — 0.001 179 vs 615 — Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    rs429358, rs7412 APOE — 0.0005 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 e4 e2 Candidate Region/Gene 18034366
    Lys751Gln ERCC2 — 0.017 149 vs 413 — Polish Mean age 101.1 homozygous (Lys/Lys, Gln/Gln) heterozygous (Lys/Gln) Candidate Region/Gene 19707883
    rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 — American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
    rs2075650 TOMM40 0.70 0.002 2307 vs 764 — American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
    rs3220637 XRCC1 — 0.0005 430 (case) vs 290 — British Mean age 70 16 — Candidate Region/Gene 16518718
    rs429358, rs7412 APOE — 0.025 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs2075650 TOMM40 0.53 2.65e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G — Genome-Wide Association Study 21418511
    rs2302951 GRWD1 1.51 7.59e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G — Genome-Wide Association Study 21740922
    rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs4802234 CEACAM16 1.36 9.22e-06 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs7246865 MYO9B 1.25 0.000164604 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs11086106 PGPEP1 1.77 0.000263101 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1674159 NDUFA11 1.41 0.000520159 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    rs429358, rs7412 APOE — 0.0212 60 vs 89 — African European Range: 20-59 — — Candidate Region/Gene 20569235

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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