Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
    Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
    TGFB1 haplotypes TGFB1 — 0.05 297 vs 130 — Turkish, Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G — Candidate Region/Gene 21299522
    TGFB1 haplotypes TGFB1 — 0.05 60 vs 40 — Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G; −988 C/C, −800 G/G — Candidate Region/Gene 21299522
    KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
    - APOC1 — 0.05 282 vs 200 — British 84 and over — — Candidate Region/Gene 9105559
    epsilon2/3/4 APOE — 0.05 67 vs 125 — Italian 99+ (mean: 100±2) epsilon4 — Candidate Region/Gene 10643896
    rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
    rs1800471 TGFB1 — 0.034 172 vs 247 — Italian 90-103 GC (genotype) — Candidate Region/Gene 15569360
    rs429358, rs7412 APOE — 0.025 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs429358, rs7412 APOE — 0.0212 60 vs 89 — African European Range: 20-59 — — Candidate Region/Gene 20569235
    APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    APOE polymorphism APOE — 0.02 80 vs 391 — Greek >80 epsilon4 — Candidate Region/Gene 17234815
    rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G — — 22234866
    Lys751Gln ERCC2 — 0.017 149 vs 413 — Polish Mean age 101.1 homozygous (Lys/Lys, Gln/Gln) heterozygous (Lys/Gln) Candidate Region/Gene 19707883
    APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    E4 APOE — 0.013 35 vs 125 — Chinese 90 years or over — — Candidate Region/Gene 11780357
    APOE e2,e3,e4 APOE 9.24 0.01 224 vs 441 — Ashkenazi Jewish 75 e4 e2 Candidate Region/Gene 15621215
    rs429358, rs7412 APOE — 0.009 1477 total — Italian 18-109 e4 non-e4 - 16896546
    rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 — American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 — Italian >88 e4 e2 Candidate Region/Gene 21703254
    rs2075650 TOMM40 0.70 0.002 2307 vs 764 — American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
    APOE e2/e4 APOE 2.00 0.001 300 vs 160 — French 100+ e4 e2 Candidate Region/Gene 8136829
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    • 25 of 46 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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