Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    TP53 TP53 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    SLC6A4 SLC6A4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    1/s 5HTT — 0.05 265 vs 225 — Japanese 101.2 S — Candidate Region/Gene 16095668
    5-HTTLPR SLC6A4 — 0.03 15 male, 53 female centenarians (cases) — Australian, Caucasian 101.0 ± 0.2 L/L (only for males) — Candidate Region/Gene 22985157
    rs1799752 ACE — 0.025 394 vs 238 — French 100.6 years Insertion — Candidate Region/Gene 9761238
    Msp1 restriction fragment length polymorphism in intron 6 (G/A) TP53 — 0.65 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    rs1042522 TP53 — 0.85 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    16 bp duplication in intron 3 (WT=no duplicaiton) TP53 — 0.59 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    rs4340 ACE 1.90 0.001 300 vs 160 — French 100+ I D Candidate Region/Gene 8136829
    rs2301582 NALP1 1.30 0.011 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603
    rs4646994 ACE 2.25 0.003 834 — Brazilian 10-104 I D (only for Gaucho population) Candidate Region/Gene 14528043

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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