Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    No Age Effect « 
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    Candidate Region/Gene (209)   Meta‑Analysis (7)   Genome‑Wide Association Study (97)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4938180 IGSF4 1.91 2.16e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2073586 ABCC8 0.48 8.15e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs189037 ATM 1.45 0.12 128 vs 150 — Italian Mean age 98.7 +/- 5.1 — — Candidate Region/Gene 22960875
    rs610932 MS4A6A — 0.176 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs3851179 PICALM — 0.227 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    • 5 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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