Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    VNTR in intron 5 (DeltaEF1 site) SIRT3 — 8e-05 242 vs 703 — Italian Median age 102 2b — Candidate Region/Gene 15676284
    VNTR in intron 5 (GATA3 site) SIRT3 — 0.025 242 vs 703 — Italian Median age 102 2a — Candidate Region/Gene 15676284
    rs4073591 DEAF1 — 0.002618 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4073590 DEAF1 — 0.004259 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs11040489 KRTAP5-6 — 0.005869 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs800140 TSPAN32 — 0.0081 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs11235972 UCP3 — 0.029 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) — Danish 93 A — Candidate Region/Gene 22743239
    rs3781907 UCP3 — 0.05 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) — Danish 93 G — Candidate Region/Gene 22743239
    rs189037 ATM 1.85 0.028 128 vs 150 — Italian — — — - 22960875
    apoAIV(360:His) APOA4 — 0.005 119 (see notes) vs 264 — French 74.29 ∓ 8.46 ApoAIV-1_x000D_, by the order of the sentence - I'm assuming it's Glutamine = G — Candidate Region/Gene 9533408
    HinfI347 APOA4 — 0.05 71 vs 100 — Italian mean102.3 years — — Candidate Region/Gene 9622284
    - TH — 0.045 202 vs 170 vs 82 — Italian 100-105 (oldest of 3 age groups, see notes) — — Candidate Region/Gene 11053670
    3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 — Italian centenarians a3 allele (see notes) — Candidate Region/Gene 11943467
    APOA1-MspI-RFLP (−75) APOA1 — 0.016 229 vs 571 — Calabrian 81–109 (median 101) A (=Absence) — Candidate Region/Gene 12556235
    rs4936894 VWA5A 1.11 3.38e-07 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — A — Genome-Wide Association Study 21782286
    rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
    rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
    rs4930001 DEAF1 — 0.010851 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs189037 ATM 1.85 0.037 67 vs 61 — Italian Centenarians — — Candidate Region/Gene 22960875
    rs2060793 CYP2R1 — 0.04 1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners) — Dutch Males: >/= 89; Females: >/= 91 — — Candidate Region/Gene 23128285
    APOC3 T455C APOC3 — 0.05 147 elderly individuals (70–106 years old) — Russian mean age: 84.6 years — — Candidate Region/Gene 11193221
    rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish mean age 98.2 A — Candidate Region/Gene 16602826
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 C — Candidate Region/Gene 22406557
    rs2509049 H2AFX 0.63 0.017 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    DRD4 7R allele DRD4 — 3.5e-08 310 vs 2909 — European mean age 95.2 years — — Candidate Region/Gene 23283341
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    • 25 of 49 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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