Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    No Age Effect « 
  • Study type: + -
    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    - HRAS1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes — — - 19367319
    - SIRT3 — 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - TH — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - INS — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - IGF2 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4073590 DEAF1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs11040489 KRTAP5-6 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs800140 TSPAN32 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    length (STR polymorphism) TH — 1.0 196 vs 358 471 vs 462 German (in replication) 96-110 years — — Candidate Region/Gene 21407269
    many SNPs TH — 0.05 1321 vs 1140 — Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) — — Candidate Region/Gene 19367319
    many SNPs IGF2 — 0.05 1321 vs 1140 — Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) — — Candidate Region/Gene 19367319
    many SNPs INS — 0.05 1321 vs 1140 — Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) — — Candidate Region/Gene 19367319
    many SNPs HRAS1 — 0.05 1321 vs 1140 — Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) — — Candidate Region/Gene 19367319
    rs939915 SIRT3 — 0.0145 2461 samples (cases and controls combined) — Italian — — — Candidate Region/Gene 19367319
    - HRAS1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes — — - 19367319
    - SIRT3 — 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - TH — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - INS — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    - IGF2 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs4073590 DEAF1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs11040489 KRTAP5-6 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs800140 TSPAN32 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
    rs189037 ATM 1.45 0.12 128 vs 150 — Italian Mean age 98.7 +/- 5.1 — — Candidate Region/Gene 22960875
    rs2073586 ABCC8 0.48 8.15e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4938180 IGSF4 1.91 2.16e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    • 25 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue