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Denigma
»
Lifespan
»
Variants
» Variant = rs699947-(−1190G/A)-rs1570360-(−634G/C)
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Mouse Lifespan Experiments
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rs699947-(−1190G/A)-rs1570360-(−634G/C)
Polymorphism:
rs699947-(−1190G/A)-rs1570360-(−634G/C)
rs699947-(−1190G/A)-rs1570360-(−634G/C)
(
SNPedia
|
23andMe
)
Variant Type:
Haplotype
Factor:
- Symbol:
VEGFA
- Name:
vascular endothelial growth factor A
- Entrez ID:
7422
- Ensembl ID:
ENSG00000112715
Ethnicity:
Italian
Age of cases:
85-99 (mean 89.8±2.8)
Shorter lived allele:
non A-A-G-G haplotypes
Longer lived allele:
A-A-G-G
Finding:
Positive
Statistics
|
332 vs 648 (replication)
- p-value:
0.03 [0.03]
- Significant:
Yes
Study Design
- Classifications:
Longevity-Associated
- Study type:
Candidate Region/Gene
- Technology:
Direct sequencing analysis of PCR fragments using BigDyeTerminatorTM protocol on an automated 3100ABI Prism Genetic Analyzer (Applied Biosystem, Foster City, CA)
Reference:
17574707: Role of VEGF gene variability in longevity: a lesson from the Italian population.
Choice:
Curate
Created:
Aug. 11, 2013, 11:29 a.m.
Updated:
Aug. 8, 2014, 1:06 p.m.
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