Polymorphism: rs699947-(−1190G/A)-rs1570360-(−634G/C)
rs699947-(−1190G/A)-rs1570360-(−634G/C)
(
SNPedia |
23andMe
)
Variant Type: Haplotype
Factor:
- Symbol: VEGFA
- Name: vascular endothelial growth factor A
- Entrez ID: 7422
- Ensembl ID: ENSG00000112715
Ethnicity:
Italian
Age of cases: 85-99 (mean 89.8±2.8)
Shorter lived allele: non A-A-G-G haplotypes
Longer lived allele: A-A-G-G
Finding: Positive
Statistics
| 332 vs 648 (replication)
- p-value:
0.03
[0.03]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Direct sequencing analysis of PCR fragments using BigDyeTerminatorTM protocol on an automated 3100ABI Prism Genetic Analyzer (Applied Biosystem, Foster City, CA)
Reference:
17574707: Role of VEGF gene variability in longevity: a lesson from the Italian population.
Choice: Curate
Created: Aug. 11, 2013, 11:29 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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