| asp-3 RNAi | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi [22810224]. | Worm | — | — | — |
| atg-7 RNAi | RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023]. | Worm | — | — | — |
| atp-2 RNAi | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Worm | +14 | — | — |
| atp-2 RNAi | Kncokdown of atp-2 via RNAi started after the animal reaches the late L4 stage increase mean lifespan by 12-18% [22103665]. | Worm | +12 to +18 | — | — |
| atp-3 RNAi | RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails to extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. atp-3 RNAi started after the animal reaches the late L4 stage increases mean lifespan by 7-8% [22103665]. | Worm | +7 to +33 | — | +70 |
| atp-4 RNAi | RNA interference of atp-4 results in lifespan extension [16103914]. | Worm | — | — | — |
| atp-5 RNAi | RNA interference of atp-5 results extended lifespan [16103914]. | Worm | — | — | — |
| ATP2 Mutation | A temperature sensitive allele of ATP2 causes a clonal senescence phenotype resulting from the disruption of the age asymmetry between mother and daughter cells in that that daughter cells are born as old as they mother cells at 36 degree Celsius. This Mutation of valine to isoleucine at amino acid 90 does not affect growth on non-fermentable carbon source. This allele is associated with loss of mitochondrial membrane potential as well as failure to segregate functional mitochondria to daughter cells [12242224]. | Worm | — | — | — |
| B0035.12 RNAi | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Worm | +12 | — | +20 |
| B0250.5 RNAi | Knockdown of B0250.5 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-14% [22103665]. | Worm | +10 to +14 | — | — |
| B0280.9 RNAi | B0280.9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| B0303.3 RNAi | Knockdown of B0303.3 via RNAi after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| B0393.6 RNAi | B0393.6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| B0491.5 RNAi | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Worm | +16 | — | — |
| B0511.6 RNAi | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Worm | +50 | — | — |
| B0546.3 RNAi | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Worm | +27 | — | — |
| baf-1 RNAi | RNA interference of baf-1 decreases median lifespan by 28% in daf-2 mutants [18006689]. | Worm | — | — | — |
| bar-1 mutation | BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404]. | Worm | -44 | — | -18 |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| beta-transducin RNAi | beta-transducin RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| blmp-1 RNAi | RNA interference of blmp-1 decreases median lifespan by 17% in a daf-2 background and 20% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -17 | — |
| bra-1 mutation | bra-1(nk1) mutation reduces mean lifespan by 6-25% [17900898]. | Worm | -6 to -25 | — | — |
| bub-3 RNAi | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Worm | +6-7 | — | +7 |
| bus-8 RNAi | RNA interference of bus-8 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -58 | — |
| C01F1.1 RNAi | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -27 | — |
GenAge
GenDR
