• name effect species mean median maximum
    (-)-epicatechin treatment Treatment with (-)-epidcatechin do no extend lifespan [20717869]. Worm
    (R)-N-(2-heptyl)-N-methylpropargylamine treatment Addition of 0.66 ng/fly/day (R)-N-(2-heptyl)-N-methylpropargylamine to a sucrose-based diet resulted in no significant effect on lifespan, but lifespan reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprenyl or (R)-N-(2-heptyl)-N-methylpropargylamine [9972869]. Fly
    14-3-3epsilon mutation Loss of 14-3-3ε results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a foxo-dependent manner. Mean lifespan of males and females is increased by 25% and 49%, respectively. Increased 14-3-3ε expression also reverts foxo-induced growth defects. No effect of lifespan is observed when overexpressing 14-3-3ε in adipose tissue, indicating that endogenous foxo activity in this tissue is low under normal conditions [18665908]. Fly +25 to +49
    2-ME treatment Animals fed a diet supplemented with 2-mercaptoethanol (2-ME) exhibit an increased mean and maximum lifespan [6334792]. T-cell-dependent immune responses are higher in the 2-ME-fed mice compared to the controls when the animals are young. The accumulation of fluorescent products of lipid peroxidation damage is also delayed in the lymphocytes of the 2-ME-fed mice and tumor onset and incidence is reduced in these animals [6334792]. Mouse
    2-MEA treatment Addition of 1% by weight 2-MEA to the diet of male LAF mice, started shortly after weaning, increases average lifespan by approximately 30%, but does not extend maximum lifespan [5723482; 11795501]. Addition of 2-MEA to the maternal diet of female mice increases the lifespan of male and female offspring by 15 and 8%, respectively [Harman & Eddy, 1979; 11795501]. Addition of 2-MEA of an antioxidant mixture containing ethoxyquin and 2-MEA to the diet of dietary restricted mice shortens lifespan approximately 20% [2394907]. Mouse +30
    272N18 Treatment 272N18 (3-(3-nitrophenyl)-11-phenyl-2,3,4,5,10,11-hexohydro-1H-dibenzo[b,e] [1,4]diazepin-1-one dihdrochloride) increases lifespan by 20%, bears a structural resemblance to certain human antidepressants that affect signalling by the neurotransmitter serotonin. Worm
    30% Dietary restriction 30% dietary restriction starting at 2 months of age increases overall, average, median and maximal lifespan. Knockout of Ghr failed to respond with lifespan extension to this regimen [16682650]. Mouse
    aak-1 mutation aak-1 does not appear to be required for the control of lifespan [15574588]. Worm
    aak-2 constitutive active mutation A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [17900900]. Worm
    aak-2 mutation aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. Worm -12 -18
    aak-2 overexpression Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. Worm +13 +25
    aakb-1 RNAi RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aakb-2 RNAi RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aakg-2 overexpression Overexpression of aakg-2 extends mean, median, and maximum lifespan by 47, 45, and 35% [22737090]. Worm +47 +45 +35
    aat-8 RNAi RNA interference of aat-8 increases mean lifespan by 30% [17608836]. Worm +30
    AAT1 overexpression Overexpression of AAT1 extends replicative lifespan by 25% and does not synergize with 0.5% glucose restriction [18381895]. Yeast +25
    abce-1 RNAi abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abcx-1 RNAi RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. Worm +16
    abi-1 RNAi abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    Ablation of median neurosecretary cells Flies with an ablation of median neurosecretary cells (which eliminates Ilp2 expression) exhibit a significant increase in mean and maximum lifespan over that of control flies and an increase to oxidative stress and starvation. The mutants also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold [15708981]. The median and maximum lifespan of females is increased by 33.5% and 40%, respectively. In males the median and maximum lifespan is increased by 10.5% and 27%, respectively [15708981]. Fly +10.5 to +33.5 +27 to +40
    ABP1 deletion ABP1 deletion increases replicative lifespan by 30% in the alpha strain and decreases replicative lifespan by 20% in the a strain [18340043]. Deletion of ABP1 increases replicative lifespan by 20% in the alpha strain and decreases replicative lifespan by 20% in the a strain [19030232]. Yeast -20 to +30
    abs-2 RNAi RNA interference of abs-2 leads to lifespan extension [16103914]. Worm
    abu-11 overexpression Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. Worm +9 to +28
    Acacb knockout Acacb-null animals (alias Acc2-/-) exhibit upon regular diet an increase triglyceride breakdown, leaner phenotype, increased insulin sensitivity and no effect on lifespan [17923673]. Mouse
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    • 25 of 1570 interventions
    Interventions are an extension of GenAge and GenDR.